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README.md
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# nnInteractive: Redefining 3D Promptable Segmentation
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This repository
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Check out the corresponding [python backend](https://github.com/MIC-DKFZ/nnInteractive).
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The backend is designed for seamless integration into Python-based workflows—ideal for researchers, developers, and power users working directly with code.
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`nnInteractive` is also available through graphical viewers (GUI) for those who prefer a visual workflow. The napari and MITK integrations are developed and maintained by our team. Thanks to the community for contributing the 3D Slicer extension!
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<div align="center">
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| **<div align="center">[napari plugin](https://github.com/MIC-DKFZ/napari-nninteractive)</div>** | **<div align="center">[MITK integration](https://www.mitk.org/wiki/MITK-nnInteractive)</div>** | **<div align="center">[3D Slicer extension](https://github.com/coendevente/SlicerNNInteractive)</div>** | **<div align="center">[ITK-SNAP extension](https://itksnap-dls.readthedocs.io/en/latest/quick_start.html)</div>** |
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| [<img src="imgs/Logos/napari.jpg" width="200">](https://github.com/MIC-DKFZ/napari-nninteractive) | [<img src="imgs/Logos/mitk.jpg" width="200">](https://www.mitk.org/wiki/MITK-nnInteractive) | [<img src="imgs/Logos/3DSlicer.png" width="200">](https://github.com/coendevente/SlicerNNInteractive) | [<img src="imgs/Logos/snaplogo_sq.png" width="200">](https://itksnap-dls.readthedocs.io/en/latest/quick_start.html) |
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</div>
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## 📰 News
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- **07/2025**: 🧩 New ITK-SNAP extension released! Try nnInteractive directly in ITK-SNAP 👉 [Quick Start](https://itksnap-dls.readthedocs.io/en/latest/quick_start.html)
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- **06/2025**: 🏆 We’re thrilled to announce that `nnInteractive` **won the 1st place** in the [CVPR 2025 Challenge on Interactive 3D Segmentation](https://www.codabench.org/competitions/5263/). Huge shoutout to the organizers and all contributors!
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- **05/2025**: `nnInteractive` presents an **official baseline** at **CVPR 2025** in the _Foundation Models for Interactive 3D Biomedical Image Segmentation Challenge_ ([Codabench link](https://www.codabench.org/competitions/5263/)) → see [`nnInteractive/inference/cvpr2025_challenge_baseline`](nnInteractive/inference/cvpr2025_challenge_baseline)
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- **04/2025**: 🎉 The **community contributed a 3D Slicer integration** – thank you! 👉 [SlicerNNInteractive](https://github.com/coendevente/SlicerNNInteractive)
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- **03/2025**: 🚀 `nnInteractive` **launched** with native support for **napari** and **MITK**
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---
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## What is nnInteractive?
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> Isensee, F.\*, Rokuss, M.\*, Krämer, L.\*, Dinkelacker, S., Ravindran, A., Stritzke, F., Hamm, B., Wald, T., Langenberg, M., Ulrich, C., Deissler, J., Floca, R., & Maier-Hein, K. (2025). nnInteractive: Redefining 3D Promptable Segmentation. https://arxiv.org/abs/2503.08373 \
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Link: [](https://arxiv.org/abs/2503.08373)
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##### Abstract:
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Accurate and efficient 3D segmentation is essential for both clinical and research applications. While foundation
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<img src="imgs/figure1_method.png" width="1200">
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### Prerequisites
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You need a Linux or Windows computer with a Nvidia GPU. 10GB of VRAM is recommended. Small objects should work with \<6GB.
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##### 1. Create a virtual environment:
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nnInteractive supports Python 3.10+ and works with Conda, pip, or any other virtual environment. Here’s an example using Conda:
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```
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conda create -n nnInteractive python=3.12
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conda activate nnInteractive
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```
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##### 2. Install the correct PyTorch for your system
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Go to the [PyTorch homepage](https://pytorch.org/get-started/locally/) and pick the right configuration.
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Note that since recently PyTorch needs to be installed via pip. This is fine to do within your conda environment.
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For Ubuntu with a Nvidia GPU, pick 'stable', 'Linux', 'Pip', 'Python', 'CUDA12.6' (if all drivers are up to date, otherwise use and older version):
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```
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pip3 install torch torchvision --index-url https://download.pytorch.org/whl/cu126
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```
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##### 3. Install this repository
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Either install via pip:
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`pip install nninteractive`
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Or clone and install this repository:
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```bash
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git clone https://github.com/MIC-DKFZ/nnInteractive
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cd nnInteractive
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pip install -e .
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```
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## Getting Started
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Here is a minimalistic script that covers the core functionality of nnInteractive:
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```python
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import
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import torch
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import SimpleITK as sitk
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from huggingface_hub import snapshot_download # Install huggingface_hub if not already installed
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# --- Download Trained Model Weights (~400MB) ---
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REPO_ID = "nnInteractive/nnInteractive"
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MODEL_NAME = "nnInteractive_v1.0" # Updated models may be available in the future
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DOWNLOAD_DIR = "/home/isensee/temp" # Specify the download directory
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download_path = snapshot_download(
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repo_id=REPO_ID,
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allow_patterns=[f"{MODEL_NAME}/*"],
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local_dir=DOWNLOAD_DIR
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)
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# The model is now stored in DOWNLOAD_DIR/MODEL_NAME.
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# --- Initialize Inference Session ---
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from nnInteractive.inference.inference_session import nnInteractiveInferenceSession
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session = nnInteractiveInferenceSession(
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device=torch.device("cuda:0"), # Set inference device
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use_torch_compile=False, # Experimental: Not tested yet
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verbose=False,
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torch_n_threads=os.cpu_count(), # Use available CPU cores
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do_autozoom=True, # Enables AutoZoom for better patching
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use_pinned_memory=True, # Optimizes GPU memory transfers
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)
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# Load the trained model
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model_path = os.path.join(DOWNLOAD_DIR, MODEL_NAME)
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session.initialize_from_trained_model_folder(model_path)
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# --- Load Input Image (Example with SimpleITK) ---
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# DO NOT preprocess the image in any way. Give it to nnInteractive as it is! DO NOT apply level window, DO NOT normalize
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# intensities and never ever convert an image with higher precision (float32, uint16, etc) to uint8!
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# The ONLY instance where some preprocesing makes sense is if your original image is too large to be reasonably used.
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# This may be the case, for example, for some microCT images. In this case you can consider downsampling.
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input_image = sitk.ReadImage("FILENAME")
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img = sitk.GetArrayFromImage(input_image)[None] # Ensure shape (1, x, y, z)
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# Validate input dimensions
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if img.ndim != 4:
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raise ValueError("Input image must be 4D with shape (1, x, y, z)")
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session.set_image(img)
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# --- Define Output Buffer ---
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target_tensor = torch.zeros(img.shape[1:], dtype=torch.uint8) # Must be 3D (x, y, z)
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session.set_target_buffer(target_tensor)
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# --- Interacting with the Model ---
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# Interactions can be freely chained and mixed in any order. Each interaction refines the segmentation.
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# The model updates the segmentation mask in the target buffer after every interaction.
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# Example: Add a **positive** point interaction
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# POINT_COORDINATES should be a tuple (x, y, z) specifying the point location.
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session.add_point_interaction(POINT_COORDINATES, include_interaction=True)
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# Example: Add a **negative** point interaction
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# To make any interaction negative set include_interaction=False
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session.add_point_interaction(POINT_COORDINATES, include_interaction=False)
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# Example: Add a bounding box interaction
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# BBOX_COORDINATES must be specified as [[x1, x2], [y1, y2], [z1, z2]] (half-open intervals).
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# Note: nnInteractive pre-trained models currently only support **2D bounding boxes**.
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# This means that **one dimension must be [d, d+1]** to indicate a single slice.
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# Example of a 2D bounding box in the axial plane (XY slice at depth Z)
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# BBOX_COORDINATES = [[30, 80], [40, 100], [10, 11]] # X: 30-80, Y: 40-100, Z: slice 10
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session.add_bbox_interaction(BBOX_COORDINATES, include_interaction=True)
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# Example: Add a scribble interaction
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# - A 3D image of the same shape as img where one slice (any axis-aligned orientation) contains a hand-drawn scribble.
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# - Background must be 0, and scribble must be 1.
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# - Use session.preferred_scribble_thickness for optimal results.
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session.add_scribble_interaction(SCRIBBLE_IMAGE, include_interaction=True)
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# Example: Add a lasso interaction
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# - Similarly to scribble a 3D image with a single slice containing a **closed contour** representing the selection.
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session.add_lasso_interaction(LASSO_IMAGE, include_interaction=True)
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# You can combine any number of interactions as needed.
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# The model refines the segmentation result incrementally with each new interaction.
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# --- Retrieve Results ---
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# The target buffer holds the segmentation result.
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results = session.target_buffer.clone()
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# OR (equivalent)
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results = target_tensor.clone()
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# Cloning is required because the buffer will be **reused** for the next object.
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# Alternatively, set a new target buffer for each object:
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session.set_target_buffer(torch.zeros(img.shape[1:], dtype=torch.uint8))
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# --- Start a New Object Segmentation ---
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session.reset_interactions() # Clears the target buffer and resets interactions
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# Now you can start segmenting the next object in the image.
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# --- Set a New Image ---
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# Setting a new image also requires setting a new matching target buffer
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session.set_image(NEW_IMAGE)
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session.set_target_buffer(torch.zeros(NEW_IMAGE.shape[1:], dtype=torch.uint8))
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# Enjoy!
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```
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As part of the `nnInteractive` framework, we provide a dedicated module for **supervoxel generation** based on [SAM](https://github.com/facebookresearch/segment-anything) and [SAM2](https://github.com/facebookresearch/sam2). This replaces traditional superpixel methods (e.g., SLIC) with **foundation model–powered 3D pseudo-labels**.
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🔗 **Module:** [`nnInteractive/supervoxel/`](nnInteractive/supervoxel)
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The SuperVoxel module allows you to:
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- Automatically generate high-quality 3D supervoxels via axial sampling + SAM segmentation and SAM2 mask propagation.
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- Use the generated supervoxels as **pseudo-ground-truth labels** to train promptable 3D segmentation models like `nnInteractive`.
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- Export `nnUNet`-compatible `.pkl` foreground prompts for downstream use.
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For detailed installation, configuration, and usage instructions, check the [SuperVoxel README](nnInteractive/supervoxel/README.md).
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## Citation
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When using nnInteractive, please cite the following paper:
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Link: [](https://arxiv.org/abs/2503.08373)
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# License
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# Changelog
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### 1.1.2 - 2025-08-02
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- Fixed a bug where `pin_memory` was set to `True` even though no CUDA devices were present (this broke CPU support)
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- ✅ API compatible all the way back to 1.0.1
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### 1.1.1 - 2025-08-01
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- We now detect whether linux kernel 6.11 is used and disable pin_memory in that case. See also [here](https://github.com/MIC-DKFZ/nnInteractive/issues/18)
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- ✅ API compatible with 1.0.1 and 1.1.0
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### 1.1.0 - 2025-08-01
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- Reworked inference code. It's now well-structured and easier to follow.
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- Fixed bugs that
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- ✅ API compatible with 1.0.1
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## Acknowledgments
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This repository is developed and maintained by the Applied Computer Vision Lab (ACVL)
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of [Helmholtz Imaging](https://www.helmholtz-imaging.de/) and the
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[Division of Medical Image Computing](https://www.dkfz.de/en/medical-image-computing) at DKFZ.
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# nnInteractive: Redefining 3D Promptable Segmentation
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This repository hosts the official model checkpoints for `nnInteractive`, a state-of-the-art framework for 3D promptable segmentation.
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> 📖 **Full documentation, installation, and usage live in the GitHub repository:**
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> 👉 **[github.com/MIC-DKFZ/nnInteractive](https://github.com/MIC-DKFZ/nnInteractive)**
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>
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> Please refer to GitHub for the Python backend, installation instructions, code examples, the SuperVoxel module, and the changelog. This page only covers downloading the checkpoint.
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`nnInteractive` is also available through graphical viewers (GUI) for those who prefer a visual workflow. The napari and MITK integrations are developed and maintained by our team. Thanks to the community for contributing further integrations!
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<div align="center">
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| **<div align="center">[napari plugin](https://github.com/MIC-DKFZ/napari-nninteractive)</div>** | **<div align="center">[MITK integration](https://www.mitk.org/wiki/MITK-nnInteractive)</div>** | **<div align="center">[3D Slicer extension](https://github.com/coendevente/SlicerNNInteractive)</div>** | **<div align="center">[ITK-SNAP extension](https://itksnap-dls.readthedocs.io/en/latest/quick_start.html)</div>** | **<div align="center">[OHIF integration](https://github.com/CCI-Bonn/OHIF-AI)</div>** |
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| [<img src="imgs/Logos/napari.jpg" width="200">](https://github.com/MIC-DKFZ/napari-nninteractive) | [<img src="imgs/Logos/mitk.jpg" width="200">](https://www.mitk.org/wiki/MITK-nnInteractive) | [<img src="imgs/Logos/3DSlicer.png" width="200">](https://github.com/coendevente/SlicerNNInteractive) | [<img src="imgs/Logos/snaplogo_sq.png" width="200">](https://itksnap-dls.readthedocs.io/en/latest/quick_start.html) | [<img src="imgs/Logos/ohif.png" width="200">](https://github.com/CCI-Bonn/OHIF-AI) |
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</div>
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---
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## What is nnInteractive?
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> Isensee, F.\*, Rokuss, M.\*, Krämer, L.\*, Dinkelacker, S., Ravindran, A., Stritzke, F., Hamm, B., Wald, T., Langenberg, M., Ulrich, C., Deissler, J., Floca, R., & Maier-Hein, K. (2025). nnInteractive: Redefining 3D Promptable Segmentation. https://arxiv.org/abs/2503.08373 \
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Link: [](https://arxiv.org/abs/2503.08373)
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##### Abstract:
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Accurate and efficient 3D segmentation is essential for both clinical and research applications. While foundation
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<img src="imgs/figure1_method.png" width="1200">
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## Downloading the checkpoint
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You normally don't need to download the weights manually — the napari, MITK, and other integrations, as well as the Python backend, fetch them for you. If you want the raw checkpoint, the snippet below pulls it from this repository:
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```python
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from huggingface_hub import snapshot_download # pip install huggingface_hub
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REPO_ID = "nnInteractive/nnInteractive"
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MODEL_NAME = "nnInteractive_v1.0" # Updated models may be available in the future
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download_path = snapshot_download(
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repo_id=REPO_ID,
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| 66 |
allow_patterns=[f"{MODEL_NAME}/*"],
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| 67 |
)
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| 68 |
+
# The checkpoint is now in download_path/MODEL_NAME.
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| 69 |
```
|
| 70 |
|
| 71 |
+
For how to actually run inference with these weights, see the [GitHub README](https://github.com/MIC-DKFZ/nnInteractive).
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| 72 |
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| 73 |
## Citation
|
| 74 |
When using nnInteractive, please cite the following paper:
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| 78 |
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| 79 |
Link: [](https://arxiv.org/abs/2503.08373)
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| 80 |
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| 81 |
# License
|
| 82 |
+
The model checkpoint hosted in this repository is licensed under `Creative Commons Attribution Non Commercial Share Alike 4.0` (CC-BY-NC-SA-4.0); see [`nnInteractive_v1.0/LICENSE`](nnInteractive_v1.0/LICENSE). Note that the [Python backend code](https://github.com/MIC-DKFZ/nnInteractive) is released separately under the Apache-2.0 license.
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| 83 |
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| 84 |
## Acknowledgments
|
| 85 |
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| 90 |
|
| 91 |
This repository is developed and maintained by the Applied Computer Vision Lab (ACVL)
|
| 92 |
of [Helmholtz Imaging](https://www.helmholtz-imaging.de/) and the
|
| 93 |
+
[Division of Medical Image Computing](https://www.dkfz.de/en/medical-image-computing) at DKFZ.
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imgs/Logos/ohif.png
ADDED
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