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Jun 29

MedQ-Bench: Evaluating and Exploring Medical Image Quality Assessment Abilities in MLLMs

Medical Image Quality Assessment (IQA) serves as the first-mile safety gate for clinical AI, yet existing approaches remain constrained by scalar, score-based metrics and fail to reflect the descriptive, human-like reasoning process central to expert evaluation. To address this gap, we introduce MedQ-Bench, a comprehensive benchmark that establishes a perception-reasoning paradigm for language-based evaluation of medical image quality with Multi-modal Large Language Models (MLLMs). MedQ-Bench defines two complementary tasks: (1) MedQ-Perception, which probes low-level perceptual capability via human-curated questions on fundamental visual attributes; and (2) MedQ-Reasoning, encompassing both no-reference and comparison reasoning tasks, aligning model evaluation with human-like reasoning on image quality. The benchmark spans five imaging modalities and over forty quality attributes, totaling 2,600 perceptual queries and 708 reasoning assessments, covering diverse image sources including authentic clinical acquisitions, images with simulated degradations via physics-based reconstructions, and AI-generated images. To evaluate reasoning ability, we propose a multi-dimensional judging protocol that assesses model outputs along four complementary axes. We further conduct rigorous human-AI alignment validation by comparing LLM-based judgement with radiologists. Our evaluation of 14 state-of-the-art MLLMs demonstrates that models exhibit preliminary but unstable perceptual and reasoning skills, with insufficient accuracy for reliable clinical use. These findings highlight the need for targeted optimization of MLLMs in medical IQA. We hope that MedQ-Bench will catalyze further exploration and unlock the untapped potential of MLLMs for medical image quality evaluation.

  • 20 authors
·
Oct 2, 2025 2

LongAV-Compass: Towards Unified Evaluation of Minute-Scale Audio-Visual Generation Across T2AV, I2AV, and V2AV

Audio-visual generation is rapidly advancing from short clips to minute-long content, while existing evaluation protocols remain largely confined to short-form settings. Existing benchmarks primarily focus on 5--10 second text-conditioned generation and rarely support unified evaluation across text, image, and video conditioning modalities. Moreover, they provide limited insight into how identity consistency, narrative coherence, and audio-visual alignment degrade over extended temporal horizons. To bridge this gap, we introduce LongAV-Compass, a systematic benchmark for minute-long audio-visual generation. LongAV-Compass contains 284 curated test cases spanning text-to-audio-video (T2AV), image-to-audio-video (I2AV), and video-to-audio-video (V2AV), organized by application scenario and generation complexity. The benchmark combines taxonomy-guided benchmark construction with a unified evaluation framework that integrates MLLM-assisted assessment with complementary perceptual and multimodal metrics, including DINO-v2, ArcFace, CLIP, and ImageBind. The framework evaluates more than 20 fine-grained dimensions covering within-segment quality, cross-segment consistency, global narrative coherence, semantic alignment, and audio-visual synchronization. Through experiments on 11 representative models together with human-alignment validation, LongAV-Compass provides a diagnostic testbed for analyzing the limitations of current systems in sustaining coherent, semantically aligned, and temporally consistent minute-scale audio-visual generation across diverse input modalities.

KlingTeam Kling Team
·
May 24 2

InstructEngine: Instruction-driven Text-to-Image Alignment

Reinforcement Learning from Human/AI Feedback (RLHF/RLAIF) has been extensively utilized for preference alignment of text-to-image models. Existing methods face certain limitations in terms of both data and algorithm. For training data, most approaches rely on manual annotated preference data, either by directly fine-tuning the generators or by training reward models to provide training signals. However, the high annotation cost makes them difficult to scale up, the reward model consumes extra computation and cannot guarantee accuracy. From an algorithmic perspective, most methods neglect the value of text and only take the image feedback as a comparative signal, which is inefficient and sparse. To alleviate these drawbacks, we propose the InstructEngine framework. Regarding annotation cost, we first construct a taxonomy for text-to-image generation, then develop an automated data construction pipeline based on it. Leveraging advanced large multimodal models and human-defined rules, we generate 25K text-image preference pairs. Finally, we introduce cross-validation alignment method, which refines data efficiency by organizing semantically analogous samples into mutually comparable pairs. Evaluations on DrawBench demonstrate that InstructEngine improves SD v1.5 and SDXL's performance by 10.53% and 5.30%, outperforming state-of-the-art baselines, with ablation study confirming the benefits of InstructEngine's all components. A win rate of over 50% in human reviews also proves that InstructEngine better aligns with human preferences.

  • 12 authors
·
Apr 14, 2025

Coresets from Trajectories: Selecting Data via Correlation of Loss Differences

Deep learning models achieve state-of-the-art performance across domains but face scalability challenges in real-time or resource-constrained scenarios. To address this, we propose Correlation of Loss Differences (CLD), a simple and scalable metric for coreset selection that identifies the most impactful training samples by measuring their alignment with the loss trajectories of a held-out validation set. CLD is highly efficient, requiring only per-sample loss values computed at training checkpoints, and avoiding the costly gradient and curvature computations used in many existing subset selection methods. We develop a general theoretical framework that establishes convergence guarantees for CLD-based coresets, demonstrating that the convergence error is upper-bounded by the alignment of the selected samples and the representativeness of the validation set. On CIFAR-100 and ImageNet-1k, CLD-based coresets typically outperform or closely match state-of-the-art methods across subset sizes, and remain within 1% of more computationally expensive baselines even when not leading. CLD transfers effectively across architectures (ResNet, VGG, DenseNet), enabling proxy-to-target selection with <1% degradation. Moreover, CLD is stable when using only early checkpoints, incurring negligible accuracy loss. Finally, CLD exhibits inherent bias reduction via per-class validation alignment, obviating the need for additional stratified sampling. Together, these properties make CLD a principled, efficient, stable, and transferable tool for scalable dataset optimization.

  • 3 authors
·
Aug 27, 2025

VibraVerse: A Large-Scale Geometry-Acoustics Alignment Dataset for Physically-Consistent Multimodal Learning

Understanding the physical world requires perceptual models grounded in physical laws rather than mere statistical correlations. However, existing multimodal learning frameworks, focused on vision and language, lack physical consistency and overlook the intrinsic causal relationships among an object's geometry, material, vibration modes, and the sounds it produces. We introduce VibraVerse, a large-scale geometry-acoustics alignment dataset that explicitly bridges the causal chain from 3D geometry -> physical attributes -> modal parameters -> acoustic signals. Each 3D model has explicit physical properties (density, Young's modulus, Poisson's ratio) and volumetric geometry, from which modal eigenfrequencies and eigenvectors are computed for impact sound synthesis under controlled excitations. To establish this coherence, we introduce CLASP, a contrastive learning framework for cross-modal alignment that preserves the causal correspondence between an object's physical structure and its acoustic response. This framework enforces physically consistent alignment across modalities, ensuring that every sample is coherent, traceable to the governing equations, and embedded within a unified representation space spanning shape, image, and sound. Built upon VibraVerse, we define a suite of benchmark tasks for geometry-to-sound prediction, sound-guided shape reconstruction, and cross-modal representation learning. Extensive validations on these tasks demonstrate that models trained on VibraVerse exhibit superior accuracy, interpretability, and generalization across modalities. These results establish VibraVerse as a benchmark for physically consistent and causally interpretable multimodal learning, providing a foundation for sound-guided embodied perception and a deeper understanding of the physical world. The dataset will be open-sourced.

  • 5 authors
·
Nov 25, 2025

Tradeoffs Between Alignment and Helpfulness in Language Models with Representation Engineering

Language model alignment has become an important component of AI safety, allowing safe interactions between humans and language models, by enhancing desired behaviors and inhibiting undesired ones. It is often done by tuning the model or inserting preset aligning prompts. Recently, representation engineering, a method which alters the model's behavior via changing its representations post-training, was shown to be effective in aligning LLMs (Zou et al., 2023a). Representation engineering yields gains in alignment oriented tasks such as resistance to adversarial attacks and reduction of social biases, but was also shown to cause a decrease in the ability of the model to perform basic tasks. In this paper we study the tradeoff between the increase in alignment and decrease in helpfulness of the model. We propose a theoretical framework which provides bounds for these two quantities, and demonstrate their relevance empirically. First, we find that under the conditions of our framework, alignment can be guaranteed with representation engineering, and at the same time that helpfulness is harmed in the process. Second, we show that helpfulness is harmed quadratically with the norm of the representation engineering vector, while the alignment increases linearly with it, indicating a regime in which it is efficient to use representation engineering. We validate our findings empirically, and chart the boundaries to the usefulness of representation engineering for alignment.

  • 6 authors
·
Jan 29, 2024

Dual-Domain Representation Alignment: Bridging 2D and 3D Vision via Geometry-Aware Architecture Search

Modern computer vision requires balancing predictive accuracy with real-time efficiency, yet the high inference cost of large vision models (LVMs) limits deployment on resource-constrained edge devices. Although Evolutionary Neural Architecture Search (ENAS) is well suited for multi-objective optimization, its practical use is hindered by two issues: expensive candidate evaluation and ranking inconsistency among subnetworks. To address them, we propose EvoNAS, an efficient distributed framework for multi-objective evolutionary architecture search. We build a hybrid supernet that integrates Vision State Space and Vision Transformer (VSS-ViT) modules, and optimize it with a Cross-Architecture Dual-Domain Knowledge Distillation (CA-DDKD) strategy. By coupling the computational efficiency of VSS blocks with the semantic expressiveness of ViT modules, CA-DDKD improves the representational capacity of the shared supernet and enhances ranking consistency, enabling reliable fitness estimation during evolution without extra fine-tuning. To reduce the cost of large-scale validation, we further introduce a Distributed Multi-Model Parallel Evaluation (DMMPE) framework based on GPU resource pooling and asynchronous scheduling. Compared with conventional data-parallel evaluation, DMMPE improves efficiency by over 70% through concurrent multi-GPU, multi-model execution. Experiments on COCO, ADE20K, KITTI, and NYU-Depth v2 show that the searched architectures, termed EvoNets, consistently achieve Pareto-optimal trade-offs between accuracy and efficiency. Compared with representative CNN-, ViT-, and Mamba-based models, EvoNets deliver lower inference latency and higher throughput under strict computational budgets while maintaining strong generalization on downstream tasks such as novel view synthesis. Code is available at https://github.com/EMI-Group/evonas

  • 6 authors
·
Mar 19

STARS: A Unified Framework for Singing Transcription, Alignment, and Refined Style Annotation

Recent breakthroughs in singing voice synthesis (SVS) have heightened the demand for high-quality annotated datasets, yet manual annotation remains prohibitively labor-intensive and resource-intensive. Existing automatic singing annotation (ASA) methods, however, primarily tackle isolated aspects of the annotation pipeline. To address this fundamental challenge, we present STARS, which is, to our knowledge, the first unified framework that simultaneously addresses singing transcription, alignment, and refined style annotation. Our framework delivers comprehensive multi-level annotations encompassing: (1) precise phoneme-audio alignment, (2) robust note transcription and temporal localization, (3) expressive vocal technique identification, and (4) global stylistic characterization including emotion and pace. The proposed architecture employs hierarchical acoustic feature processing across frame, word, phoneme, note, and sentence levels. The novel non-autoregressive local acoustic encoders enable structured hierarchical representation learning. Experimental validation confirms the framework's superior performance across multiple evaluation dimensions compared to existing annotation approaches. Furthermore, applications in SVS training demonstrate that models utilizing STARS-annotated data achieve significantly enhanced perceptual naturalness and precise style control. This work not only overcomes critical scalability challenges in the creation of singing datasets but also pioneers new methodologies for controllable singing voice synthesis. Audio samples are available at https://gwx314.github.io/stars-demo/.

  • 9 authors
·
Jul 9, 2025

4D Diffusion for Dynamic Protein Structure Prediction with Reference Guided Motion Alignment

Protein structure prediction is pivotal for understanding the structure-function relationship of proteins, advancing biological research, and facilitating pharmaceutical development and experimental design. While deep learning methods and the expanded availability of experimental 3D protein structures have accelerated structure prediction, the dynamic nature of protein structures has received limited attention. This study introduces an innovative 4D diffusion model incorporating molecular dynamics (MD) simulation data to learn dynamic protein structures. Our approach is distinguished by the following components: (1) a unified diffusion model capable of generating dynamic protein structures, including both the backbone and side chains, utilizing atomic grouping and side-chain dihedral angle predictions; (2) a reference network that enhances structural consistency by integrating the latent embeddings of the initial 3D protein structures; and (3) a motion alignment module aimed at improving temporal structural coherence across multiple time steps. To our knowledge, this is the first diffusion-based model aimed at predicting protein trajectories across multiple time steps simultaneously. Validation on benchmark datasets demonstrates that our model exhibits high accuracy in predicting dynamic 3D structures of proteins containing up to 256 amino acids over 32 time steps, effectively capturing both local flexibility in stable states and significant conformational changes.

  • 9 authors
·
Aug 22, 2024

BenSyc: Benchmarking Conversational Sycophancy and Human Alignment in LLMs for Bengali Contexts

Large language models (LLMs) increasingly participate in emotionally sensitive social conversations, where responses may shift from balanced support toward excessive validation or escalatory alignment. Existing sycophancy research primarily focuses on factual agreement and instruction-following settings, leaving culturally grounded conversational sycophancy underexplored. We introduce BenSyc, the first benchmark for studying conversational sycophancy in Bengali social contexts. Starting from 11,840 Reddit posts and 170k comments collected from communities across Bangladesh and West Bengal, we construct a human-validated benchmark with binary labels and a fine-grained five-level taxonomy spanning Invalidation, Neutral, Support, Validation, and Escalation. We evaluate more than 15 open and proprietary LLMs on conversational alignment classification and response generation tasks. Results show that distinguishing empathetic support from reinforcement-oriented validation remains challenging even for frontier instruction-tuned models: the best system achieves only 61.8 Macro-F1 on binary detection and 61.7 Macro-F1 on five-class classification. In generation settings, several models frequently produce strongly validating or escalatory responses in emotionally charged situations. Our findings highlight substantial variation across model families and conversational behaviors, underscoring the importance of culturally grounded multilingual benchmarks for evaluating socially aligned conversational AI systems.

SERV-CT: A disparity dataset from CT for validation of endoscopic 3D reconstruction

In computer vision, reference datasets have been highly successful in promoting algorithmic development in stereo reconstruction. Surgical scenes gives rise to specific problems, including the lack of clear corner features, highly specular surfaces and the presence of blood and smoke. Publicly available datasets have been produced using CT and either phantom images or biological tissue samples covering a relatively small region of the endoscope field-of-view. We present a stereo-endoscopic reconstruction validation dataset based on CT (SERV-CT). Two {\it ex vivo} small porcine full torso cadavers were placed within the view of the endoscope with both the endoscope and target anatomy visible in the CT scan. Orientation of the endoscope was manually aligned to the stereoscopic view. Reference disparities and occlusions were calculated for 8 stereo pairs from each sample. For the second sample an RGB surface was acquired to aid alignment of smooth, featureless surfaces. Repeated manual alignments showed an RMS disparity accuracy of ~2 pixels and a depth accuracy of ~2mm. The reference dataset includes endoscope image pairs with corresponding calibration, disparities, depths and occlusions covering the majority of the endoscopic image and a range of tissue types. Smooth specular surfaces and images with significant variation of depth are included. We assessed the performance of various stereo algorithms from online available repositories. There is a significant variation between algorithms, highlighting some of the challenges of surgical endoscopic images. The SERV-CT dataset provides an easy to use stereoscopic validation for surgical applications with smooth reference disparities and depths with coverage over the majority of the endoscopic images. This complements existing resources well and we hope will aid the development of surgical endoscopic anatomical reconstruction algorithms.

  • 5 authors
·
Dec 21, 2020

Model-Task Alignment Drives Distinct RL Outcomes

Recent advances in applying reinforcement learning (RL) to large language models (LLMs) have led to substantial progress. In particular, a series of remarkable yet often counterintuitive phenomena have been reported in LLMs, exhibiting patterns not typically observed in traditional RL settings. For example, notable claims include that a single training example can match the performance achieved with an entire dataset, that the reward signal does not need to be very accurate, and that training solely with negative samples can match or even surpass sophisticated reward-based methods. However, the precise conditions under which these observations hold - and, critically, when they fail - remain unclear. In this work, we identify a key factor that differentiates RL observations: whether the pretrained model already exhibits strong Model-Task Alignment, as measured by pass@k accuracy on the evaluated task. Through a systematic and comprehensive examination of a series of counterintuitive claims, supported by rigorous experimental validation across different model architectures and task domains, our findings show that while standard RL training remains consistently robust across settings, many of these counterintuitive results arise only when the model and task already exhibit strong model-task alignment. In contrast, these techniques fail to drive substantial learning in more challenging regimes, where standard RL methods remain effective.

  • 4 authors
·
Aug 28, 2025 2

MMA-ASIA: A Multilingual and Multimodal Alignment Framework for Culturally-Grounded Evaluation

Large language models (LLMs) are now used worldwide, yet their multimodal understanding and reasoning often degrade outside Western, high-resource settings. We propose MMA-ASIA, a comprehensive framework to evaluate LLMs' cultural awareness with a focus on Asian contexts. MMA-ASIA centers on a human-curated, multilingual, and multimodally aligned multiple-choice benchmark covering 8 Asian countries and 10 languages, comprising 27,000 questions; over 79 percent require multi-step reasoning grounded in cultural context, moving beyond simple memorization. To our knowledge, this is the first dataset aligned at the input level across three modalities: text, image (visual question answering), and speech. This enables direct tests of cross-modal transfer. Building on this benchmark, we propose a five-dimensional evaluation protocol that measures: (i) cultural-awareness disparities across countries, (ii) cross-lingual consistency, (iii) cross-modal consistency, (iv) cultural knowledge generalization, and (v) grounding validity. To ensure rigorous assessment, a Cultural Awareness Grounding Validation Module detects "shortcut learning" by checking whether the requisite cultural knowledge supports correct answers. Finally, through comparative model analysis, attention tracing, and an innovative Vision-ablated Prefix Replay (VPR) method, we probe why models diverge across languages and modalities, offering actionable insights for building culturally reliable multimodal LLMs.

  • 35 authors
·
Oct 6, 2025

Expert-level validation of AI-generated medical text with scalable language models

With the growing use of language models (LMs) in clinical environments, there is an immediate need to evaluate the accuracy and safety of LM-generated medical text. Currently, such evaluation relies solely on manual physician review. However, detecting errors in LM-generated text is challenging because 1) manual review is costly and 2) expert-composed reference outputs are often unavailable in real-world settings. While the "LM-as-judge" paradigm (a LM evaluating another LM) offers scalable evaluation, even frontier LMs can miss subtle but clinically significant errors. To address these challenges, we propose MedVAL, a self-supervised framework that leverages synthetic data to train evaluator LMs to assess whether LM-generated medical outputs are factually consistent with inputs, without requiring physician labels or reference outputs. To evaluate LM performance, we introduce MedVAL-Bench, a dataset containing 840 outputs annotated by physicians, following a physician-defined taxonomy of risk levels and error categories. Across 6 diverse medical tasks and 10 state-of-the-art LMs spanning open-source, proprietary, and medically adapted models, MedVAL fine-tuning significantly improves (p < 0.001) alignment with physicians on both seen and unseen tasks, increasing average F1 scores from 66% to 83%, with per-sample safety classification scores up to 86%. MedVAL improves the performance of even the best-performing proprietary LM (GPT-4o) by 8%. To support a scalable, risk-aware pathway towards clinical integration, we open-source the 1) codebase ( https://github.com/StanfordMIMI/MedVAL ), 2) MedVAL-Bench ( https://huggingface.co/datasets/stanfordmimi/MedVAL-Bench ), and 3) MedVAL-4B ( https://huggingface.co/stanfordmimi/MedVAL-4B ), the best-performing open-source LM. Our research provides the first evidence of LMs approaching expert-level validation ability for medical text.

  • 27 authors
·
Jul 3, 2025

Bridging the Gap Between Preference Alignment and Machine Unlearning

Despite advances in Preference Alignment (PA) for Large Language Models (LLMs), mainstream methods like Reinforcement Learning with Human Feedback (RLHF) face notable challenges. These approaches require high-quality datasets of positive preference examples, which are costly to obtain and computationally intensive due to training instability, limiting their use in low-resource scenarios. LLM unlearning technique presents a promising alternative, by directly removing the influence of negative examples. However, current research has primarily focused on empirical validation, lacking systematic quantitative analysis. To bridge this gap, we propose a framework to explore the relationship between PA and LLM unlearning. Specifically, we introduce a bi-level optimization-based method to quantify the impact of unlearning specific negative examples on PA performance. Our analysis reveals that not all negative examples contribute equally to alignment improvement when unlearned, and the effect varies significantly across examples. Building on this insight, we pose a crucial question: how can we optimally select and weight negative examples for unlearning to maximize PA performance? To answer this, we propose a framework called Unlearning to Align (U2A), which leverages bi-level optimization to efficiently select and unlearn examples for optimal PA performance. We validate the proposed method through extensive experiments, with results confirming its effectiveness.

  • 7 authors
·
Apr 8, 2025

SDOF: Taming the Alignment Tax in Multi-Agent Orchestration with State-Constrained Dispatch

Multi-agent orchestration frameworks such as LangChain, LangGraph, and CrewAI route tasks through graph-based pipelines but do not enforce the stage constraints that govern real business processes. We present SDOF, a framework that treats multi-agent execution as a constrained state machine. SDOF operates through two primary defensive layers, implemented by three components: (1) an Online-RLHF Specialized Intent Router trained via Generative Reward Modeling (GRPO) and (2) a StateAwareDispatcher with GoalStage finite-automaton checks and precondition/postcondition SkillRegistry validation for auditable execution control. On a recruitment system backed by the Beisen iTalent platform (6000+ enterprises), 185 expert-curated scenarios trigger 1671 live API calls. Our GSPO-aligned 7B Intent Router achieves higher joint accuracy than zero-shot GPT-4o on this FSM-constrained adversarial routing benchmark (80.9% versus 48.9%). In end-to-end execution, SDOF reaches 86.5% task completion (95% confidence interval 80.8 to 90.7) and blocks all 22 operations in the injection, illegal HR subset. Under a broader message-level blocking audit, SDOF attains precision 100% and recall 88%, expert agreement kappa=0.94. A separate evaluation on 960 SGD-derived dialogues spanning 8 service domains surfaces 201 stage-order conflicts under our FSM mapping, 41 of which arise in the normal split. This arXiv version reports the current validated scope; extended multi-seed training comparisons and deeper workflow evaluations will be released in a subsequent update.

  • 1 authors
·
Apr 19

SAGE-RT: Synthetic Alignment data Generation for Safety Evaluation and Red Teaming

We introduce Synthetic Alignment data Generation for Safety Evaluation and Red Teaming (SAGE-RT or SAGE) a novel pipeline for generating synthetic alignment and red-teaming data. Existing methods fall short in creating nuanced and diverse datasets, providing necessary control over the data generation and validation processes, or require large amount of manually generated seed data. SAGE addresses these limitations by using a detailed taxonomy to produce safety-alignment and red-teaming data across a wide range of topics. We generated 51,000 diverse and in-depth prompt-response pairs, encompassing over 1,500 topics of harmfulness and covering variations of the most frequent types of jailbreaking prompts faced by large language models (LLMs). We show that the red-teaming data generated through SAGE jailbreaks state-of-the-art LLMs in more than 27 out of 32 sub-categories, and in more than 58 out of 279 leaf-categories (sub-sub categories). The attack success rate for GPT-4o, GPT-3.5-turbo is 100% over the sub-categories of harmfulness. Our approach avoids the pitfalls of synthetic safety-training data generation such as mode collapse and lack of nuance in the generation pipeline by ensuring a detailed coverage of harmful topics using iterative expansion of the topics and conditioning the outputs on the generated raw-text. This method can be used to generate red-teaming and alignment data for LLM Safety completely synthetically to make LLMs safer or for red-teaming the models over a diverse range of topics.

  • 7 authors
·
Aug 14, 2024

KNN-MMD: Cross Domain Wireless Sensing via Local Distribution Alignment

Wireless sensing has recently found widespread applications in diverse environments, including homes, offices, and public spaces. By analyzing patterns in channel state information (CSI), it is possible to infer human actions for tasks such as person identification, gesture recognition, and fall detection. However, CSI is highly sensitive to environmental changes, where even minor alterations can significantly distort the CSI patterns. This sensitivity often leads to performance degradation or outright failure when applying wireless sensing models trained in one environment to another. To address this challenge, Domain Alignment (DAL) has been widely adopted for cross-domain classification tasks, as it focuses on aligning the global distributions of the source and target domains in feature space. Despite its popularity, DAL often neglects inter-category relationships, which can lead to misalignment between categories across domains, even when global alignment is achieved. To overcome these limitations, we propose K-Nearest Neighbors Maximum Mean Discrepancy (KNN-MMD), a novel few-shot method for cross-domain wireless sensing. Our approach begins by constructing a help set using KNN from the target domain, enabling local alignment between the source and target domains within each category using MMD. Additionally, we address a key instability issue commonly observed in cross-domain methods, where model performance fluctuates sharply between epochs. Further, most existing methods struggle to determine an optimal stopping point during training due to the absence of labeled data from the target domain. Our method resolves this by excluding the support set from the target domain during training and employing it as a validation set to determine the stopping criterion.The dataset and code are publicly available at https://github.com/RS2002/KNN-MMD .

  • 7 authors
·
Dec 6, 2024

COIG-P: A High-Quality and Large-Scale Chinese Preference Dataset for Alignment with Human Values

Aligning large language models (LLMs) with human preferences has achieved remarkable success. However, existing Chinese preference datasets are limited by small scale, narrow domain coverage, and lack of rigorous data validation. Additionally, the reliance on human annotators for instruction and response labeling significantly constrains the scalability of human preference datasets. To address these challenges, we design an LLM-based Chinese preference dataset annotation pipeline with no human intervention. Specifically, we crawled and carefully filtered 92k high-quality Chinese queries and employed 15 mainstream LLMs to generate and score chosen-rejected response pairs. Based on it, we introduce COIG-P (Chinese Open Instruction Generalist - Preference), a high-quality, large-scale Chinese preference dataset, comprises 1,009k Chinese preference pairs spanning 6 diverse domains: Chat, Code, Math, Logic, Novel, and Role. Building upon COIG-P, to reduce the overhead of using LLMs for scoring, we trained a 8B-sized Chinese Reward Model (CRM) and meticulously constructed a Chinese Reward Benchmark (CRBench). Evaluation results based on AlignBench liu2024alignbenchbenchmarkingchinesealignment show that that COIG-P significantly outperforms other Chinese preference datasets, and it brings significant performance improvements ranging from 2% to 12% for the Qwen2/2.5 and Infinity-Instruct-3M-0625 model series, respectively. The results on CRBench demonstrate that our CRM has a strong and robust scoring ability. We apply it to filter chosen-rejected response pairs in a test split of COIG-P, and our experiments show that it is comparable to GPT-4o in identifying low-quality samples while maintaining efficiency and cost-effectiveness. Our codes and data are released in https://github.com/multimodal-art-projection/COIG-P.

  • 32 authors
·
Apr 7, 2025 2

Can LLMs Express Personality Across Cultures? Introducing CulturalPersonas for Evaluating Trait Alignment

As LLMs become central to interactive applications, ranging from tutoring to mental health, the ability to express personality in culturally appropriate ways is increasingly important. While recent works have explored personality evaluation of LLMs, they largely overlook the interplay between culture and personality. To address this, we introduce CulturalPersonas, the first large-scale benchmark with human validation for evaluating LLMs' personality expression in culturally grounded, behaviorally rich contexts. Our dataset spans 3,000 scenario-based questions across six diverse countries, designed to elicit personality through everyday scenarios rooted in local values. We evaluate three LLMs, using both multiple-choice and open-ended response formats. Our results show that CulturalPersonas improves alignment with country-specific human personality distributions (over a 20% reduction in Wasserstein distance across models and countries) and elicits more expressive, culturally coherent outputs compared to existing benchmarks. CulturalPersonas surfaces meaningful modulated trait outputs in response to culturally grounded prompts, offering new directions for aligning LLMs to global norms of behavior. By bridging personality expression and cultural nuance, we envision that CulturalPersonas will pave the way for more socially intelligent and globally adaptive LLMs.

  • 5 authors
·
Oct 12, 2025

CleanMAP: Distilling Multimodal LLMs for Confidence-Driven Crowdsourced HD Map Updates

The rapid growth of intelligent connected vehicles (ICVs) and integrated vehicle-road-cloud systems has increased the demand for accurate, real-time HD map updates. However, ensuring map reliability remains challenging due to inconsistencies in crowdsourced data, which suffer from motion blur, lighting variations, adverse weather, and lane marking degradation. This paper introduces CleanMAP, a Multimodal Large Language Model (MLLM)-based distillation framework designed to filter and refine crowdsourced data for high-confidence HD map updates. CleanMAP leverages an MLLM-driven lane visibility scoring model that systematically quantifies key visual parameters, assigning confidence scores (0-10) based on their impact on lane detection. A novel dynamic piecewise confidence-scoring function adapts scores based on lane visibility, ensuring strong alignment with human evaluations while effectively filtering unreliable data. To further optimize map accuracy, a confidence-driven local map fusion strategy ranks and selects the top-k highest-scoring local maps within an optimal confidence range (best score minus 10%), striking a balance between data quality and quantity. Experimental evaluations on a real-world autonomous vehicle dataset validate CleanMAP's effectiveness, demonstrating that fusing the top three local maps achieves the lowest mean map update error of 0.28m, outperforming the baseline (0.37m) and meeting stringent accuracy thresholds (<= 0.32m). Further validation with real-vehicle data confirms 84.88% alignment with human evaluators, reinforcing the model's robustness and reliability. This work establishes CleanMAP as a scalable and deployable solution for crowdsourced HD map updates, ensuring more precise and reliable autonomous navigation. The code will be available at https://Ankit-Zefan.github.io/CleanMap/

  • 8 authors
·
Apr 14, 2025

SynGP500: A Clinically-Grounded Synthetic Dataset of Australian General Practice Medical Notes

We introduce SynGP500, a clinician-curated collection of 500 synthetic Australian general practice medical notes. The dataset integrates curriculum-based clinical breadth (RACGP 2022 Curriculum), epidemiologically-calibrated prevalence (BEACH study), and diverse consultation contexts. This approach systematically includes both common presentations and less-common curriculum-specified conditions that GPs must recognize but appear infrequently in single practice populations, potentially supporting more generalizable model training than datasets constrained by naturally occurring case distributions. SynGP500 is messy by design, reflecting the authentic complexity of healthcare delivery: telegraphic documentation, typos, patient non-adherence, socioeconomic barriers, and clinician-patient disagreements, unlike sanitized synthetic datasets that obscure clinical realities. Multi-faceted validation demonstrates dataset quality through epidemiological alignment with real Australian GP consultation patterns (BEACH study), stylometric analysis confirming high linguistic variation, semantic diversity analysis demonstrating broad coverage, and exploratory downstream evaluation using self-supervised medical concept extraction, showing F1 improvements. SynGP500 addresses a critical national gap, providing researchers and educators with a resource for developing and evaluating clinical NLP methods for Australian general practice while inherently protecting patient privacy.

  • 1 authors
·
Dec 17, 2025

Socratic-SWE: Self-Evolving Coding Agents via Trace-Derived Agent Skills

LLM-driven software engineering agents have become a central testbed for real-world language-model capability, yet their training remains limited by the availability of high-quality SWE tasks. Existing synthetic data methods typically create tasks through fixed mutation or bug-injection procedures, making the resulting distributions largely independent of the agent's own weaknesses and training progress. We introduce Socratic-SWE, a closed-loop self-evolution framework that reuses the agent's historical solving traces as a source of training signal. Rather than treating traces only as evidence for reward computation, Socratic-SWE distills them into structured agent skills that summarize recurring failures and effective repair patterns. These skills then guide the generation of targeted repair tasks in real repositories. Candidate tasks are checked through execution-based validation and scored with a solver-gradient alignment reward, so that the retained tasks are both verifiable and useful for improving the Solver. The updated Solver produces new traces, enabling the task curriculum to adapt over successive rounds. Across SWE-bench Verified, SWE-bench Lite, SWE-bench Pro, and Terminal-Bench 2.0, Socratic-SWE consistently improves over self-evolving baselines under the same compute budget, reaching 50.40% on SWE-bench Verified after three iterations. These results suggest that solving traces can serve as a scalable substrate for self-evolving SWE agents.

  • 8 authors
·
Jun 4 3

SARLO-80: Worldwide Slant SAR Language Optic Dataset 80cm

Multimodal foundation models have advanced rapidly thanks to large optical benchmarks, but comparable resources for synthetic aperture radar (SAR) remain limited. Existing SAR--optical datasets largely rely on low-resolution, intensity-only Ground Range Detected~(GRD) products and do not preserve complex-valued SAR measurements or native acquisition geometry, which restricts physically grounded multimodal learning. In particular, large-scale public datasets combining very-high-resolution (VHR) SAR SLC, aligned optical imagery, and natural-language descriptions are still lacking. We present a VHR SAR--optical--text dataset built from open-access Umbra spotlight acquisitions distributed as Sensor Independent Complex Data (SICD). From around 2,500 worldwide scenes (VV/HH, 20cm--2m native resolution), we standardize all SAR data to an 80cm slant-range grid via band-limited FFT resampling and tile the imagery into 1024 by 1024 patches. For each SAR patch, we retrieve a high-resolution optical tile and warp it into the SAR grid using local coordinate correspondences for local pixel-level alignment. We further generate three caption variants (SHORT/MID/LONG) per sample to support vision--language training and evaluation. Our dataset contains 119,566 triplets (complex and amplitude slant-range SAR patch, aligned optical patch, natural-language description) covering 257 locations across 72 countries and a broad range of land types and infrastructures. We release fixed train/validation/test splits and the full preprocessing and baseline code to enable reproducible benchmarks for multimodal alignment on cross-modal retrieval and conditional generation in native SAR geometry. The dataset is publicly available on the Hugging Face Hub at https://huggingface.co/datasets/ONERA/SARLO-80.

  • 5 authors
·
Jun 17

Why Registration Quality Matters: Enhancing sCT Synthesis with IMPACT-Based Registration

We participated in the SynthRAD2025 challenge (Tasks 1 and 2) with a unified pipeline for synthetic CT (sCT) generation from MRI and CBCT, implemented using the KonfAI framework. Our model is a 2.5D U-Net++ with a ResNet-34 encoder, trained jointly across anatomical regions and fine-tuned per region. The loss function combined pixel-wise L1 loss with IMPACT-Synth, a perceptual loss derived from SAM and TotalSegmentator to enhance structural fidelity. Training was performed using AdamW (initial learning rate = 0.001, halved every 25k steps) on patch-based, normalized, body-masked inputs (320x320 for MRI, 256x256 for CBCT), with random flipping as the only augmentation. No post-processing was applied. Final predictions leveraged test-time augmentation and five-fold ensembling. The best model was selected based on validation MAE. Two registration strategies were evaluated: (i) Elastix with mutual information, consistent with the challenge pipeline, and (ii) IMPACT, a feature-based similarity metric leveraging pretrained segmentation networks. On the local test sets, IMPACT-based registration achieved more accurate and anatomically consistent alignments than mutual-information-based registration, resulting in improved sCT synthesis with lower MAE and more realistic anatomical structures. On the public validation set, however, models trained with Elastix-aligned data achieved higher scores, reflecting a registration bias favoring alignment strategies consistent with the evaluation pipeline. This highlights how registration errors can propagate into supervised learning, influencing both training and evaluation, and potentially inflating performance metrics at the expense of anatomical fidelity. By promoting anatomically consistent alignment, IMPACT helps mitigate this bias and supports the development of more robust and generalizable sCT synthesis models.

  • 4 authors
·
Oct 24, 2025

GIST: Targeted Data Selection for Instruction Tuning via Coupled Optimization Geometry

Targeted data selection has emerged as a crucial paradigm for efficient instruction tuning, aiming to identify a small yet influential subset of training examples for a specific target task. In practice, influence is often measured through the effect of an example on parameter updates. To make selection scalable, many approaches leverage optimizer statistics (e.g., Adam states) as an axis-aligned surrogate for update geometry (i.e., diagonal precondition), implicitly treating parameters as coordinate-wise independent. We show that this assumption breaks down in parameter-efficient fine-tuning (PEFT) methods such as LoRA. In this setting, the induced optimization geometry exhibits strong cross-parameter coupling with non-trivial off-diagonal interactions, while the task-relevant update directions are confined to a low-dimensional subspace. Motivated by this mismatch, we propose GIST (Gradient Isometric Subspace Transformation), a simple yet principled alternative that replaces axis-aligned scaling with robust subspace alignment. GIST recovers a task-specific subspace from validation gradients via spectral filtering (SVD), projects training gradients into this coupled subspace, and scores examples by their alignment with target directions.Extensive experiments have demonstrated that GIST matches or outperforms the state-of-the-art baseline with only 0.29% of the storage and 25% of the computational time under the same selection budget.

ComfyGPT: A Self-Optimizing Multi-Agent System for Comprehensive ComfyUI Workflow Generation

ComfyUI provides a widely-adopted, workflow-based interface that enables users to customize various image generation tasks through an intuitive node-based architecture. However, the intricate connections between nodes and diverse modules often present a steep learning curve for users. In this paper, we introduce ComfyGPT, the first self-optimizing multi-agent system designed to generate ComfyUI workflows based on task descriptions automatically. ComfyGPT comprises four specialized agents: ReformatAgent, FlowAgent, RefineAgent, and ExecuteAgent. The core innovation of ComfyGPT lies in two key aspects. First, it focuses on generating individual node links rather than entire workflows, significantly improving generation precision. Second, we proposed FlowAgent, a LLM-based workflow generation agent that uses both supervised fine-tuning (SFT) and reinforcement learning (RL) to improve workflow generation accuracy. Moreover, we introduce FlowDataset, a large-scale dataset containing 13,571 workflow-description pairs, and FlowBench, a comprehensive benchmark for evaluating workflow generation systems. We also propose four novel evaluation metrics: Format Validation (FV), Pass Accuracy (PA), Pass Instruct Alignment (PIA), and Pass Node Diversity (PND). Experimental results demonstrate that ComfyGPT significantly outperforms existing LLM-based methods in workflow generation.

  • 9 authors
·
Mar 22, 2025

FaGeL: Fabric LLMs Agent empowered Embodied Intelligence Evolution with Autonomous Human-Machine Collaboration

Recent advancements in Large Language Models (LLMs) have enhanced the reasoning capabilities of embodied agents, driving progress toward AGI-powered robotics. While LLMs have been applied to tasks like semantic reasoning and task generalization, their potential in open physical space exploration remains underexplored. This paper introduces FaGeL (Fabric aGent empowered by embodied intelligence with LLMs), an embodied agent integrating smart fabric technology for seamless, non-intrusive human-agent interaction. FaGeL autonomously generates tasks using multimodal data from wearable and ambient sensors, refining its behavior based on implicit human feedback in generated text, without explicit ratings or preferences. We also introduce a token-level saliency map to visualize LLM fine-tuning, enhancing the interpretability of token-level alignment. The system leverages dual feedback mechanisms to improve token-level alignment and addresses challenges in non-intrusive human-machine interaction and cognition evolution. Our contributions include FaGeL's development, the DualCUT algorithm for AI alignment, and experimental validation in cooperative tasks, demonstrating FaGeL's ability to adapt and evolve autonomously through implicit feedback. In the future, we plan to explore FaGeL's scalability in dynamic environments and its integration with other AI systems to develop AGI agents that adapt seamlessly to diverse human needs.

  • 2 authors
·
Dec 28, 2024

D-Judge: How Far Are We? Evaluating the Discrepancies Between AI-synthesized Images and Natural Images through Multimodal Guidance

In the rapidly evolving field of Artificial Intelligence Generated Content (AIGC), a central challenge is distinguishing AI-synthesized images from natural images. Despite the impressive capabilities of advanced AI generative models in producing visually compelling content, significant discrepancies remain when compared to natural images. To systematically investigate and quantify these differences, we construct a large-scale multimodal dataset named DANI, comprising 5,000 natural images and over 440,000 AI-generated image (AIGI) samples produced by nine representative models using both unimodal and multimodal prompts, including Text-to-Image (T2I), Image-to-Image (I2I), and Text and Image-to-Image (TI2I). We then introduce D-Judge, a benchmark designed to answer the critical question: how far are AI-generated images from truly realistic images? Our fine-grained evaluation framework assesses DANI across five key dimensions: naive visual quality, semantic alignment, aesthetic appeal, downstream task applicability, and coordinated human validation. Extensive experiments reveal substantial discrepancies across these dimensions, highlighting the importance of aligning quantitative metrics with human judgment to achieve a comprehensive understanding of AI-generated image quality. The code and dataset are publicly available at: https://github.com/ryliu68/DJudge and https://huggingface.co/datasets/Renyang/DANI.

  • 4 authors
·
Dec 23, 2024

Toward Safe and Responsible AI Agents: A Three-Pillar Model for Transparency, Accountability, and Trustworthiness

This paper presents a conceptual and operational framework for developing and operating safe and trustworthy AI agents based on a Three-Pillar Model grounded in transparency, accountability, and trustworthiness. Building on prior work in Human-in-the-Loop systems, reinforcement learning, and collaborative AI, the framework defines an evolutionary path toward autonomous agents that balances increasing automation with appropriate human oversight. The paper argues that safe agent autonomy must be achieved through progressive validation, analogous to the staged development of autonomous driving, rather than through immediate full automation. Transparency and accountability are identified as foundational requirements for establishing user trust and for mitigating known risks in generative AI systems, including hallucinations, data bias, and goal misalignment, such as the inversion problem. The paper further describes three ongoing work streams supporting this framework: public deliberation on AI agents conducted by the Stanford Deliberative Democracy Lab, cross-industry collaboration through the Safe AI Agent Consortium, and the development of open tooling for an agent operating environment aligned with the Three-Pillar Model. Together, these contributions provide both conceptual clarity and practical guidance for enabling the responsible evolution of AI agents that operate transparently, remain aligned with human values, and sustain societal trust.

  • 3 authors
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Jan 8

Seeing, Signing, and Saying: A Vision-Language Model-Assisted Pipeline for Sign Language Data Acquisition and Curation from Social Media

Most existing sign language translation (SLT) datasets are limited in scale, lack multilingual coverage, and are costly to curate due to their reliance on expert annotation and controlled recording setup. Recently, Vision Language Models (VLMs) have demonstrated strong capabilities as evaluators and real-time assistants. Despite these advancements, their potential remains untapped in the context of sign language dataset acquisition. To bridge this gap, we introduce the first automated annotation and filtering framework that utilizes VLMs to reduce reliance on manual effort while preserving data quality. Our method is applied to TikTok videos across eight sign languages and to the already curated YouTube-SL-25 dataset in German Sign Language for the purpose of additional evaluation. Our VLM-based pipeline includes a face visibility detection, a sign activity recognition, a text extraction from video content, and a judgment step to validate alignment between video and text, implementing generic filtering, annotation and validation steps. Using the resulting corpus, TikTok-SL-8, we assess the performance of two off-the-shelf SLT models on our filtered dataset for German and American Sign Languages, with the goal of establishing baselines and evaluating the robustness of recent models on automatically extracted, slightly noisy data. Our work enables scalable, weakly supervised pretraining for SLT and facilitates data acquisition from social media.

  • 4 authors
·
Oct 29, 2025

Math Agents: Computational Infrastructure, Mathematical Embedding, and Genomics

The advancement in generative AI could be boosted with more accessible mathematics. Beyond human-AI chat, large language models (LLMs) are emerging in programming, algorithm discovery, and theorem proving, yet their genomics application is limited. This project introduces Math Agents and mathematical embedding as fresh entries to the "Moore's Law of Mathematics", using a GPT-based workflow to convert equations from literature into LaTeX and Python formats. While many digital equation representations exist, there's a lack of automated large-scale evaluation tools. LLMs are pivotal as linguistic user interfaces, providing natural language access for human-AI chat and formal languages for large-scale AI-assisted computational infrastructure. Given the infinite formal possibility spaces, Math Agents, which interact with math, could potentially shift us from "big data" to "big math". Math, unlike the more flexible natural language, has properties subject to proof, enabling its use beyond traditional applications like high-validation math-certified icons for AI alignment aims. This project aims to use Math Agents and mathematical embeddings to address the ageing issue in information systems biology by applying multiscalar physics mathematics to disease models and genomic data. Generative AI with episodic memory could help analyse causal relations in longitudinal health records, using SIR Precision Health models. Genomic data is suggested for addressing the unsolved Alzheimer's disease problem.

  • 4 authors
·
Jul 4, 2023

P-Aligner: Enabling Pre-Alignment of Language Models via Principled Instruction Synthesis

Large Language Models (LLMs) are expected to produce safe, helpful, and honest content during interaction with human users, but they frequently fail to align with such values when given flawed instructions, e.g., missing context, ambiguous directives, or inappropriate tone, leaving substantial room for improvement along multiple dimensions. A cost-effective yet high-impact way is to pre-align instructions before the model begins decoding. Existing approaches either rely on prohibitive test-time search costs or end-to-end model rewrite, which is powered by a customized training corpus with unclear objectives. In this work, we demonstrate that the goal of efficient and effective preference alignment can be achieved by P-Aligner, a lightweight module generating instructions that preserve the original intents while being expressed in a more human-preferred form. P-Aligner is trained on UltraPrompt, a new dataset synthesized via a proposed principle-guided pipeline using Monte-Carlo Tree Search, which systematically explores the space of candidate instructions that are closely tied to human preference. Experiments across different methods show that P-Aligner generally outperforms strong baselines across various models and benchmarks, including average win-rate gains of 28.35% and 8.69% on GPT-4-turbo and Gemma-2-SimPO, respectively. Further analyses validate its effectiveness and efficiency through multiple perspectives, including data quality, search strategies, iterative deployment, and time overhead.

  • 9 authors
·
Aug 6, 2025

From Instructions to Intrinsic Human Values -- A Survey of Alignment Goals for Big Models

Big models, exemplified by Large Language Models (LLMs), are models typically pre-trained on massive data and comprised of enormous parameters, which not only obtain significantly improved performance across diverse tasks but also present emergent capabilities absent in smaller models. However, the growing intertwining of big models with everyday human lives poses potential risks and might cause serious social harm. Therefore, many efforts have been made to align LLMs with humans to make them better follow user instructions and satisfy human preferences. Nevertheless, `what to align with' has not been fully discussed, and inappropriate alignment goals might even backfire. In this paper, we conduct a comprehensive survey of different alignment goals in existing work and trace their evolution paths to help identify the most essential goal. Particularly, we investigate related works from two perspectives: the definition of alignment goals and alignment evaluation. Our analysis encompasses three distinct levels of alignment goals and reveals a goal transformation from fundamental abilities to value orientation, indicating the potential of intrinsic human values as the alignment goal for enhanced LLMs. Based on such results, we further discuss the challenges of achieving such intrinsic value alignment and provide a collection of available resources for future research on the alignment of big models.

  • 5 authors
·
Aug 23, 2023

Alignment and Safety in Large Language Models: Safety Mechanisms, Training Paradigms, and Emerging Challenges

Due to the remarkable capabilities and growing impact of large language models (LLMs), they have been deeply integrated into many aspects of society. Thus, ensuring their alignment with human values and intentions has emerged as a critical challenge. This survey provides a comprehensive overview of practical alignment techniques, training protocols, and empirical findings in LLM alignment. We analyze the development of alignment methods across diverse paradigms, characterizing the fundamental trade-offs between core alignment objectives. Our analysis shows that while supervised fine-tuning enables basic instruction-following, preference-based methods offer more flexibility for aligning with nuanced human intent. We discuss state-of-the-art techniques, including Direct Preference Optimization (DPO), Constitutional AI, brain-inspired methods, and alignment uncertainty quantification (AUQ), highlighting their approaches to balancing quality and efficiency. We review existing evaluation frameworks and benchmarking datasets, emphasizing limitations such as reward misspecification, distributional robustness, and scalable oversight. We summarize strategies adopted by leading AI labs to illustrate the current state of practice. We conclude by outlining open problems in oversight, value pluralism, robustness, and continuous alignment. This survey aims to inform both researchers and practitioners navigating the evolving landscape of LLM alignment.

  • 50 authors
·
Jul 25, 2025

Aligning Multimodal LLM with Human Preference: A Survey

Large language models (LLMs) can handle a wide variety of general tasks with simple prompts, without the need for task-specific training. Multimodal Large Language Models (MLLMs), built upon LLMs, have demonstrated impressive potential in tackling complex tasks involving visual, auditory, and textual data. However, critical issues related to truthfulness, safety, o1-like reasoning, and alignment with human preference remain insufficiently addressed. This gap has spurred the emergence of various alignment algorithms, each targeting different application scenarios and optimization goals. Recent studies have shown that alignment algorithms are a powerful approach to resolving the aforementioned challenges. In this paper, we aim to provide a comprehensive and systematic review of alignment algorithms for MLLMs. Specifically, we explore four key aspects: (1) the application scenarios covered by alignment algorithms, including general image understanding, multi-image, video, and audio, and extended multimodal applications; (2) the core factors in constructing alignment datasets, including data sources, model responses, and preference annotations; (3) the benchmarks used to evaluate alignment algorithms; and (4) a discussion of potential future directions for the development of alignment algorithms. This work seeks to help researchers organize current advancements in the field and inspire better alignment methods. The project page of this paper is available at https://github.com/BradyFU/Awesome-Multimodal-Large-Language-Models/tree/Alignment.

  • 17 authors
·
Mar 18, 2025 3

Extracting alignment data in open models

In this work, we show that it is possible to extract significant amounts of alignment training data from a post-trained model -- useful to steer the model to improve certain capabilities such as long-context reasoning, safety, instruction following, and maths. While the majority of related work on memorisation has focused on measuring success of training data extraction through string matching, we argue that embedding models are better suited for our specific goals. Distances measured through a high quality embedding model can identify semantic similarities between strings that a different metric such as edit distance will struggle to capture. In fact, in our investigation, approximate string matching would have severely undercounted (by a conservative estimate of 10times) the amount of data that can be extracted due to trivial artifacts that deflate the metric. Interestingly, we find that models readily regurgitate training data that was used in post-training phases such as SFT or RL. We show that this data can be then used to train a base model, recovering a meaningful amount of the original performance. We believe our work exposes a possibly overlooked risk towards extracting alignment data. Finally, our work opens up an interesting discussion on the downstream effects of distillation practices: since models seem to be regurgitating aspects of their training set, distillation can therefore be thought of as indirectly training on the model's original dataset.

google Google
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Oct 21, 2025 5

AlignScore: Evaluating Factual Consistency with a Unified Alignment Function

Many text generation applications require the generated text to be factually consistent with input information. Automatic evaluation of factual consistency is challenging. Previous work has developed various metrics that often depend on specific functions, such as natural language inference (NLI) or question answering (QA), trained on limited data. Those metrics thus can hardly assess diverse factual inconsistencies (e.g., contradictions, hallucinations) that occur in varying inputs/outputs (e.g., sentences, documents) from different tasks. In this paper, we propose AlignScore, a new holistic metric that applies to a variety of factual inconsistency scenarios as above. AlignScore is based on a general function of information alignment between two arbitrary text pieces. Crucially, we develop a unified training framework of the alignment function by integrating a large diversity of data sources, resulting in 4.7M training examples from 7 well-established tasks (NLI, QA, paraphrasing, fact verification, information retrieval, semantic similarity, and summarization). We conduct extensive experiments on large-scale benchmarks including 22 evaluation datasets, where 19 of the datasets were never seen in the alignment training. AlignScore achieves substantial improvement over a wide range of previous metrics. Moreover, AlignScore (355M parameters) matches or even outperforms metrics based on ChatGPT and GPT-4 that are orders of magnitude larger.

  • 4 authors
·
May 26, 2023

Efficient Alignment of Large Language Models via Data Sampling

LLM alignment ensures that large language models behave safely and effectively by aligning their outputs with human values, goals, and intentions. Aligning LLMs employ huge amounts of data, computation, and time. Moreover, curating data with human feedback is expensive and takes time. Recent research depicts the benefit of data engineering in the fine-tuning and pre-training paradigms to bring down such costs. However, alignment differs from the afore-mentioned paradigms and it is unclear if data efficient alignment is feasible. In this work, we first aim to understand how the performance of LLM alignment scales with data. We find out that LLM alignment performance follows an exponential plateau pattern which tapers off post a rapid initial increase. Based on this, we identify data subsampling as a viable method to reduce resources required for alignment. Further, we propose an information theory-based methodology for efficient alignment by identifying a small high quality subset thereby reducing the computation and time required by alignment. We evaluate the proposed methodology over multiple datasets and compare the results. We find that the model aligned using our proposed methodology outperforms other sampling methods and performs comparable to the model aligned with the full dataset while using less than 10% data, leading to greater than 90% savings in costs, resources, and faster LLM alignment.

  • 3 authors
·
Nov 15, 2024

Align With Purpose: Optimize Desired Properties in CTC Models with a General Plug-and-Play Framework

Connectionist Temporal Classification (CTC) is a widely used criterion for training supervised sequence-to-sequence (seq2seq) models. It enables learning the relations between input and output sequences, termed alignments, by marginalizing over perfect alignments (that yield the ground truth), at the expense of imperfect alignments. This binary differentiation of perfect and imperfect alignments falls short of capturing other essential alignment properties that hold significance in other real-world applications. Here we propose Align With Purpose, a general Plug-and-Play framework for enhancing a desired property in models trained with the CTC criterion. We do that by complementing the CTC with an additional loss term that prioritizes alignments according to a desired property. Our method does not require any intervention in the CTC loss function, enables easy optimization of a variety of properties, and allows differentiation between both perfect and imperfect alignments. We apply our framework in the domain of Automatic Speech Recognition (ASR) and show its generality in terms of property selection, architectural choice, and scale of training dataset (up to 280,000 hours). To demonstrate the effectiveness of our framework, we apply it to two unrelated properties: emission time and word error rate (WER). For the former, we report an improvement of up to 570ms in latency optimization with a minor reduction in WER, and for the latter, we report a relative improvement of 4.5% WER over the baseline models. To the best of our knowledge, these applications have never been demonstrated to work on a scale of data as large as ours. Notably, our method can be implemented using only a few lines of code, and can be extended to other alignment-free loss functions and to domains other than ASR.

  • 11 authors
·
Jul 4, 2023

Large Language Model Alignment: A Survey

Recent years have witnessed remarkable progress made in large language models (LLMs). Such advancements, while garnering significant attention, have concurrently elicited various concerns. The potential of these models is undeniably vast; however, they may yield texts that are imprecise, misleading, or even detrimental. Consequently, it becomes paramount to employ alignment techniques to ensure these models to exhibit behaviors consistent with human values. This survey endeavors to furnish an extensive exploration of alignment methodologies designed for LLMs, in conjunction with the extant capability research in this domain. Adopting the lens of AI alignment, we categorize the prevailing methods and emergent proposals for the alignment of LLMs into outer and inner alignment. We also probe into salient issues including the models' interpretability, and potential vulnerabilities to adversarial attacks. To assess LLM alignment, we present a wide variety of benchmarks and evaluation methodologies. After discussing the state of alignment research for LLMs, we finally cast a vision toward the future, contemplating the promising avenues of research that lie ahead. Our aspiration for this survey extends beyond merely spurring research interests in this realm. We also envision bridging the gap between the AI alignment research community and the researchers engrossed in the capability exploration of LLMs for both capable and safe LLMs.

  • 9 authors
·
Sep 26, 2023

Aligning Large Language Models with Human: A Survey

Large Language Models (LLMs) trained on extensive textual corpora have emerged as leading solutions for a broad array of Natural Language Processing (NLP) tasks. Despite their notable performance, these models are prone to certain limitations such as misunderstanding human instructions, generating potentially biased content, or factually incorrect (hallucinated) information. Hence, aligning LLMs with human expectations has become an active area of interest within the research community. This survey presents a comprehensive overview of these alignment technologies, including the following aspects. (1) Data collection: the methods for effectively collecting high-quality instructions for LLM alignment, including the use of NLP benchmarks, human annotations, and leveraging strong LLMs. (2) Training methodologies: a detailed review of the prevailing training methods employed for LLM alignment. Our exploration encompasses Supervised Fine-tuning, both Online and Offline human preference training, along with parameter-efficient training mechanisms. (3) Model Evaluation: the methods for evaluating the effectiveness of these human-aligned LLMs, presenting a multifaceted approach towards their assessment. In conclusion, we collate and distill our findings, shedding light on several promising future research avenues in the field. This survey, therefore, serves as a valuable resource for anyone invested in understanding and advancing the alignment of LLMs to better suit human-oriented tasks and expectations. An associated GitHub link collecting the latest papers is available at https://github.com/GaryYufei/AlignLLMHumanSurvey.

  • 9 authors
·
Jul 24, 2023

AI Alignment at Your Discretion

In AI alignment, extensive latitude must be granted to annotators, either human or algorithmic, to judge which model outputs are `better' or `safer.' We refer to this latitude as alignment discretion. Such discretion remains largely unexamined, posing two risks: (i) annotators may use their power of discretion arbitrarily, and (ii) models may fail to mimic this discretion. To study this phenomenon, we draw on legal concepts of discretion that structure how decision-making authority is conferred and exercised, particularly in cases where principles conflict or their application is unclear or irrelevant. Extended to AI alignment, discretion is required when alignment principles and rules are (inevitably) conflicting or indecisive. We present a set of metrics to systematically analyze when and how discretion in AI alignment is exercised, such that both risks (i) and (ii) can be observed. Moreover, we distinguish between human and algorithmic discretion and analyze the discrepancy between them. By measuring both human and algorithmic discretion over safety alignment datasets, we reveal layers of discretion in the alignment process that were previously unaccounted for. Furthermore, we demonstrate how algorithms trained on these datasets develop their own forms of discretion in interpreting and applying these principles, which challenges the purpose of having any principles at all. Our paper presents the first step towards formalizing this core gap in current alignment processes, and we call on the community to further scrutinize and control alignment discretion.

  • 6 authors
·
Feb 10, 2025

Ensuring Safe and High-Quality Outputs: A Guideline Library Approach for Language Models

Large Language Models (LLMs) exhibit impressive capabilities but also present risks such as biased content generation and privacy issues. One of the current alignment techniques includes principle-driven integration, but it faces challenges arising from the imprecision of manually crafted rules and inadequate risk perception in models without safety training. To address these, we introduce Guide-Align, a two-stage approach. Initially, a safety-trained model identifies potential risks and formulates specific guidelines for various inputs, establishing a comprehensive library of guidelines and a model for input-guidelines retrieval. Subsequently, the retrieval model correlates new inputs with relevant guidelines, which guide LLMs in response generation to ensure safe and high-quality outputs, thereby aligning with human values. An additional optional stage involves fine-tuning a model with well-aligned datasets generated through the process implemented in the second stage. Our method customizes guidelines to accommodate diverse inputs, thereby enhancing the fine-grainedness and comprehensiveness of the guideline library. Furthermore, it incorporates safety expertise from a safety-trained LLM through a lightweight retrieval model. We evaluate our approach on three benchmarks, demonstrating significant improvements in LLM security and quality. Notably, our fine-tuned model, Labrador, even at 13 billion parameters, outperforms GPT-3.5-turbo and surpasses GPT-4 in alignment capabilities.

  • 10 authors
·
Mar 18, 2024

Alignment Quality Index (AQI) : Beyond Refusals: AQI as an Intrinsic Alignment Diagnostic via Latent Geometry, Cluster Divergence, and Layer wise Pooled Representations

Alignment is no longer a luxury, it is a necessity. As large language models (LLMs) enter high-stakes domains like education, healthcare, governance, and law, their behavior must reliably reflect human-aligned values and safety constraints. Yet current evaluations rely heavily on behavioral proxies such as refusal rates, G-Eval scores, and toxicity classifiers, all of which have critical blind spots. Aligned models are often vulnerable to jailbreaking, stochasticity of generation, and alignment faking. To address this issue, we introduce the Alignment Quality Index (AQI). This novel geometric and prompt-invariant metric empirically assesses LLM alignment by analyzing the separation of safe and unsafe activations in latent space. By combining measures such as the Davies-Bouldin Score (DBS), Dunn Index (DI), Xie-Beni Index (XBI), and Calinski-Harabasz Index (CHI) across various formulations, AQI captures clustering quality to detect hidden misalignments and jailbreak risks, even when outputs appear compliant. AQI also serves as an early warning signal for alignment faking, offering a robust, decoding invariant tool for behavior agnostic safety auditing. Additionally, we propose the LITMUS dataset to facilitate robust evaluation under these challenging conditions. Empirical tests on LITMUS across different models trained under DPO, GRPO, and RLHF conditions demonstrate AQI's correlation with external judges and ability to reveal vulnerabilities missed by refusal metrics. We make our implementation publicly available to foster future research in this area.

  • 15 authors
·
Jun 16, 2025 2

Targeting Alignment: Extracting Safety Classifiers of Aligned LLMs

Alignment in large language models (LLMs) is used to enforce guidelines such as safety. Yet, alignment fails in the face of jailbreak attacks that modify inputs to induce unsafe outputs. In this paper, we present and evaluate a method to assess the robustness of LLM alignment. We observe that alignment embeds a safety classifier in the target model that is responsible for deciding between refusal and compliance. We seek to extract an approximation of this classifier, called a surrogate classifier, from the LLM. We develop an algorithm for identifying candidate classifiers from subsets of the LLM model. We evaluate the degree to which the candidate classifiers approximate the model's embedded classifier in benign (F1 score) and adversarial (using surrogates in a white-box attack) settings. Our evaluation shows that the best candidates achieve accurate agreement (an F1 score above 80%) using as little as 20% of the model architecture. Further, we find attacks mounted on the surrogate models can be transferred with high accuracy. For example, a surrogate using only 50% of the Llama 2 model achieved an attack success rate (ASR) of 70%, a substantial improvement over attacking the LLM directly, where we only observed a 22% ASR. These results show that extracting surrogate classifiers is a viable (and highly effective) means for modeling (and therein addressing) the vulnerability of aligned models to jailbreaking attacks.

  • 5 authors
·
Jan 27, 2025

Polarity-Aware Probing for Quantifying Latent Alignment in Language Models

Advances in unsupervised probes such as Contrast-Consistent Search (CCS), which reveal latent beliefs without relying on token outputs, raise the question of whether these methods can reliably assess model alignment. We investigate this by examining the sensitivity of CCS to harmful vs. safe statements and by introducing Polarity-Aware CCS (PA-CCS), a method for evaluating whether a model's internal representations remain consistent under polarity inversion. We propose two alignment-oriented metrics, Polar-Consistency and the Contradiction Index, to quantify the semantic robustness of a model's latent knowledge. To validate PA-CCS, we curate two main datasets and one control dataset containing matched harmful-safe sentence pairs constructed using different methodologies (concurrent and antagonistic statements). We apply PA-CCS to 16 language models. Our results show that PA-CCS identifies both architectural and layer-specific differences in the encoding of latent harmful knowledge. Notably, replacing the negation token with a meaningless marker degrades PA-CCS scores for models with well-aligned internal representations, while models lacking robust internal calibration do not exhibit this degradation. Our findings highlight the potential of unsupervised probing for alignment evaluation and emphasize the need to incorporate structural robustness checks into interpretability benchmarks. Code and datasets are available at: https://github.com/SadSabrina/polarity-probing. WARNING: This paper contains potentially sensitive, harmful, and offensive content.

  • 3 authors
·
Nov 21, 2025

Alignment for Honesty

Recent research has made significant strides in applying alignment techniques to enhance the helpfulness and harmlessness of large language models (LLMs) in accordance with human intentions. In this paper, we argue for the importance of alignment for honesty, ensuring that LLMs proactively refuse to answer questions when they lack knowledge, while still not being overly conservative. However, a pivotal aspect of alignment for honesty involves discerning the limits of an LLM's knowledge, which is far from straightforward. This challenge demands comprehensive solutions in terms of metric development, benchmark creation, and training methodologies. In this paper, we address these challenges by first establishing a precise problem definition and defining ``honesty'' inspired by the Analects of Confucius. This serves as a cornerstone for developing metrics that effectively measure an LLM's honesty by quantifying its progress post-alignment. Furthermore, we introduce a flexible training framework which is further instantiated by several efficient fine-tuning techniques that emphasize honesty without sacrificing performance on other tasks. Our extensive experiments reveal that these aligned models show a marked increase in honesty, as indicated by our proposed metrics. We open-source a wealth of resources to facilitate future research at https://github.com/GAIR-NLP/alignment-for-honesty, including honesty-aligned models, training and evaluation datasets for honesty alignment, concept glossary, as well as all relevant source code.

  • 5 authors
·
Dec 12, 2023

Weak-to-Strong Generalization beyond Accuracy: a Pilot Study in Safety, Toxicity, and Legal Reasoning

As large language models (LLMs) continue to advance, ensuring their alignment with human values becomes increasingly critical. Traditional alignment methods heavily rely on human feedback to fine-tune models. With the emergence of superhuman models whose outputs may surpass human understanding, evaluating and aligning these models using human judgments poses significant challenges. To address the challenges, recent works use weak supervisors to elicit knowledge from much stronger models. However, there are important disanalogies between the empirical setup in the existing works and the genuine goal of alignment. We remark that existing works investigate the phenomenon of weak-to-strong generation in analogous setup (i.e., binary classification), rather than practical alignment-relevant tasks (e.g., safety). In this paper, we bridge this gap by extending weak-to-strong generation to the context of practical alignment. We empirically demonstrate the widespread phenomenon of weak-to-strong generation in three complicated alignment tasks: safety, toxicity, and legal reasoning}. Furthermore, we explore efficient strategies for improving alignment performance to enhance the quality of model outcomes. Lastly, we summarize and analyze the challenges and potential solutions in regard to specific alignment tasks, which we hope to catalyze the research progress on the topic of weak-to-strong generalization. Our code is released at https://github.com/yeruimeng/WTS.git.

  • 3 authors
·
Oct 16, 2024

InfAlign: Inference-aware language model alignment

Language model alignment has become a critical step in training modern generative language models. The goal of alignment is to finetune a reference model such that the win rate of a sample from the aligned model over a sample from the reference model is high, subject to a KL divergence constraint. Today, we are increasingly using inference-time algorithms (e.g., Best-of-N, controlled decoding, tree search) to decode from language models rather than standard sampling. However, the alignment objective does not capture such inference-time decoding procedures. We show that the existing alignment framework is sub-optimal in view of such inference-time methods. We then modify the alignment objective and propose a framework for inference-aware alignment (IAPO). We prove that for any inference-time decoding algorithm, the optimal solution that optimizes the inference-time win rate of the aligned policy against the reference policy is the solution to the typical RLHF problem with a transformation of the reward. This motivates us to provide the KL-regularized calibrate-and-transform RL (CTRL) algorithm to solve this problem, which involves a reward calibration step and a KL-regularized reward maximization step with a transformation of the calibrated reward. We particularize our study to two important inference-time strategies: best-of-N sampling and best-of-N jailbreaking, where N responses are sampled from the model and the one with the highest or lowest reward is selected. We propose specific transformations for these strategies and demonstrate that our framework offers significant improvements over existing state-of-the-art methods for language model alignment. Empirically, we outperform baselines that are designed without taking inference-time decoding into consideration by 8-12% and 4-9% on inference-time win rates over the Anthropic helpfulness and harmlessness dialog benchmark datasets.

  • 12 authors
·
Dec 27, 2024

The Wrong Kind of Right: Quantifying and Localizing Misfired Alignment in LLMs

Warning: This paper studies stereotypes and biases, and contains potentially disturbing examples, used for illustration purposes only. Our findings should not be interpreted as an argument against alignment. Instead, this paper highlights the need for principled approaches to more advanced alignment. Alignment aims to ensure that large language models (LLMs) behave safely and reliably, including by avoiding unsafe inferences. However, we show that such safety-oriented behaviors can misfire: models may reject warranted conclusions even when they are explicitly supported by context. We call this failure mode misfired alignment, where alignment-induced changes cause LLMs to override explicit evidence. To quantify this phenomenon, specifically on stereotype-related alignment, we introduce VETO, a benchmark consisting of 2,032 BBQ-derived contrastive pairs, and define a new metric, Misfired Alignment Rate (MAR), which measures on a 0 to 100 scale how often a model fails on a stereotype-related question but succeeds on its contrastive counterpart. We benchmark 25 LLMs on VETO, and show that all LLMs, including the most recent ones, exhibit non-trivial (4.7 to 18.9%) MARs while all human participants achieve 0.0% MAR. Controlled priming experiments further show that alignment-induced cues can substantially amplify MAR across LLMs, indicating that these failures are not merely artifacts of individual examples but can be induced by safety-related framing. Mechanistic analyses on open-weight LLMs reveal late-layer suppression of evidence-supported answers, and comparisons between instruct and base LLMs suggest that this suppression emerges after instruction training. These findings show that current alignment methods can overgeneralize surface-level safety cues, to the point of overriding objective evidence, motivating more work on alignment objectives that better preserve contextual grounding.

  • 7 authors
·
Jun 16

Baichuan Alignment Technical Report

We introduce Baichuan Alignment, a detailed analysis of the alignment techniques employed in the Baichuan series of models. This represents the industry's first comprehensive account of alignment methodologies, offering valuable insights for advancing AI research. We investigate the critical components that enhance model performance during the alignment process, including optimization methods, data strategies, capability enhancements, and evaluation processes. The process spans three key stages: Prompt Augmentation System (PAS), Supervised Fine-Tuning (SFT), and Preference Alignment. The problems encountered, the solutions applied, and the improvements made are thoroughly recorded. Through comparisons across well-established benchmarks, we highlight the technological advancements enabled by Baichuan Alignment. Baichuan-Instruct is an internal model, while Qwen2-Nova-72B and Llama3-PBM-Nova-70B are instruct versions of the Qwen2-72B and Llama-3-70B base models, optimized through Baichuan Alignment. Baichuan-Instruct demonstrates significant improvements in core capabilities, with user experience gains ranging from 17% to 28%, and performs exceptionally well on specialized benchmarks. In open-source benchmark evaluations, both Qwen2-Nova-72B and Llama3-PBM-Nova-70B consistently outperform their respective official instruct versions across nearly all datasets. This report aims to clarify the key technologies behind the alignment process, fostering a deeper understanding within the community. Llama3-PBM-Nova-70B model is available at https://huggingface.co/PKU-Baichuan-MLSystemLab/Llama3-PBM-Nova-70B.

  • 25 authors
·
Oct 18, 2024 2

I-SHEEP: Self-Alignment of LLM from Scratch through an Iterative Self-Enhancement Paradigm

Large Language Models (LLMs) have achieved significant advancements, however, the common learning paradigm treats LLMs as passive information repositories, neglecting their potential for active learning and alignment. Some approaches train LLMs using their own generated synthetic data, exploring the possibility of active alignment. However, there is still a huge gap between these one-time alignment methods and the continuous automatic alignment of humans. In this paper, we introduce I-SHEEP, an Iterative Self-EnHancEmEnt Paradigm.This human-like paradigm enables LLMs to continuously self-align from scratch with nothing. Compared to the one-time alignment method Dromedary sun2023principledriven, which refers to the first iteration in this paper, I-SHEEP can significantly enhance capacities on both Qwen and Llama models. I-SHEEP achieves a maximum relative improvement of 78.2\% in the Alpaca Eval, 24.0\% in the MT Bench, and an absolute increase of 8.88\% in the IFEval accuracy over subsequent iterations in Qwen-1.5 72B model. Additionally, I-SHEEP surpasses the base model in various standard benchmark generation tasks, achieving an average improvement of 24.77\% in code generation tasks, 12.04\% in TrivialQA, and 20.29\% in SQuAD. We also provide new insights based on the experiment results. Our codes, datasets, and models are available at https://anonymous.4open.science/r/I-SHEEP.

  • 12 authors
·
Aug 15, 2024 2

Efficient Response Generation Method Selection for Fine-Tuning Large Language Models

The training data for fine-tuning large language models (LLMs) is typically structured as input-output pairs. However, for many tasks, there can be multiple equally valid output variations for the same input. Recent studies have observed that the choice of output variation used in training can affect the model's performance. This raises an important question: how can we generate the most effective output from the many possible response generation strategy options? Rather than relying on the traditional but resource-intensive train-and-evaluate approach, this paper proposes a scalable, approximate method for estimating the quality of a small subset of generated training data derived from the same input. We then evaluate how well this small subset of generated output fits the target model we are trying to train. We present a large-scale benchmark covering diverse reasoning-based datasets to support our study. The central idea is that a good output should closely resemble the output generated by the target LLM. We formalize this 'closeness' as the expected alignment score between a candidate output and the output sampled from the target LLM. We connect this measurement to the perplexity metric used in previous literature and demonstrate that leveraging an alignment-based metric can provide better predictions of model performance. Using this strategy, we can evaluate a small subset of the generated output from each response generation strategy option, then select the most effective strategy. We show that an LLM trained on data generated by the selected strategy could lead to a significant performance gain in many cases.

  • 3 authors
·
Feb 17, 2025

Find Central Dogma Again

In recent years, large language models (LLMs) have achieved state-of-the-art results in various biological sequence analysis tasks, such as sequence classification, structure prediction, and function prediction. Similar to advancements in AI for other scientific fields, deeper research into biological LLMs has begun to focus on using these models to rediscover important existing biological laws or uncover entirely new patterns in biological sequences.This study leverages GPT-like LLMs to utilize language transfer capabilities to rediscover the genetic code rules of the central dogma. In our experimental design, we transformed the central dogma into a binary classification problem of aligning DNA sequences with protein sequences, where positive examples are matching DNA and protein sequences, and negative examples are non-matching pairs.We first trained a GPT-2 model from scratch using a dataset comprising protein sequences, DNA sequences, and sequences from languages such as English and Chinese. Subsequently, we fine-tuned the model using the English similarity judgment dataset from PAWS-X. When tested on a dataset for DNA and protein sequence alignment judgment, the fine-tuned model achieved a classification accuracy of 76%. The study also analyzed factors contributing to this zero-shot capability, including model training stability and types of training data.This research demonstrates that LLMs can, through the transfer of natural language capabilities and solely relying on the analysis of sequences themselves, rediscover the central dogma without prior knowledge of it. This study opens a new door for AI-driven biological research.

  • 1 authors
·
Feb 10, 2025